A double-blind randomised investigation of Tibolone alone or in adjunct to standard antidepressant treatment for depression in menopausal women

Subject area of study: 
Depression
Title of study: 
A double-blind randomised investigation of Tibolone alone or in adjunct to standard antidepressant treatment for depression in menopausal women
Brief outline of the study: 

All women experience menopause and a significant number suffer from ongoing, severe depression beginning with the major hormone fluctuations in the middle stage of life. Many women with this type of depression are commonly treated with standard antidepressant medication. However, this form of treatment has historically only shown small improvements in this group. Hormone treatments which directly target the changes to reproductive hormone systems may have significant potential as a better overall treatment of perimenopausal depression. Therefore it is of great interest and value to examine whether the use of hormone medication (Tibolone) will aid standard antidepressants in treating depression after a relapsing, or occurring for the first time, during the perimenopause phase but are still persisting.
Menopausal women aged 45-55 and experiencing symptoms of depression are invited to take part in this 12 week study consisting of 3 face-to-face appointments, & several phone appointments.

Department: 
Monash Alfred Psychiatry Research Centre (MAPrc)
Recruitment start date: 
Thu, 22/12/2016
Recruitment end date: 
Thu, 31/12/2020
Contact person title: 
Ms
Contact person first name: 
Emmy
Contact person last name: 
Gavrilidis
Contact email: 
maprc.wmhresearch@monash.edu
Contact phone number: 
(03) 9076 6913
Website link: 
http://www.maprc.org.au/tibolone
Ethics Committee Project Number: 
485/11
Do you have advertising approval?: 
Yes
Approved by: 
Alfred